3O3D

Human Class I MHC HLA-A2 in complex with the Peptidomimetic ELA-2

3O3D の概要

• エントリーDOI: 10.2210/pdb3o3d/pdb
• 関連するPDBエントリー: 2GT9 3O3A 3O3B 3O3E
• 分子名称: HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, Peptidomimetic ELA-2, ... (5 entities in total)
• 機能のキーワード: mart peptides, nonapeptide, mhc class i, hla-a2, peptidomimetics, cross-reactivity, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P01892; Secreted: P61769
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 89941.95

構造登録者

Borbulevych, O.Y.,Baker, B.M. (登録日: 2010-07-23, 公開日: 2010-12-08, 最終更新日: 2024-10-30)

主引用文献

Douat-Casassus, C.,Borbulevych, O.,Tarbe, M.,Gervois, N.,Jotereau, F.,Baker, B.M.,Quideau, S.
Crystal structures of HLA-A*0201 complexed with Melan-A/MART-1(26(27L)-35) peptidomimetics reveal conformational heterogeneity and highlight degeneracy of T cell recognition.
J.Med.Chem., 53:7061-7066, 2010

PubMed Abstract: There is growing interest in using tumor associated antigens presented by class I major histocompatibility complex (MHC-I) proteins as cancer vaccines. As native peptides are poorly stable in biological fluids, researchers have sought to engineer synthetic peptidomimetics with greater biostability. Here, we demonstrate that antigenic peptidomimetics of the Melan-A/MART-1(26(27L)-35) melanoma antigen adopt strikingly different conformations when bound to MHC-I, highlighting the degeneracy of T cell recognition and revealing the challenges associated with mimicking native peptide conformation.

PubMed: 20806940
DOI: 10.1021/jm100683p

実験手法

X-RAY DIFFRACTION (1.7 Å)