3O23

Human unphosphorylated IGF1-R Kinase domain in complex with an hydantoin inhibitor

3O23 の概要

• エントリーDOI: 10.2210/pdb3o23/pdb
• 関連するPDBエントリー: 3LVP
• 分子名称: Insulin-like growth factor 1 receptor, (5S)-5-methyl-1-(quinolin-4-ylmethyl)-3-{4-[(trifluoromethyl)sulfonyl]phenyl}imidazolidine-2,4-dione (3 entities in total)
• 機能のキーワード: protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P08069
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35258.34

構造登録者

Maignan, S.,Guilloteau, J.P.,Dupuy, A. (登録日: 2010-07-22, 公開日: 2011-05-04, 最終更新日: 2023-11-01)

• 主引用文献: Lesuisse, D.,Mauger, J.,Nemecek, C.,Maignan, S.,Boiziau, J.,Harlow, G.,Hittinger, A.,Ruf, S.,Strobel, H.,Nair, A.,Ritter, K.,Malleron, J.L.,Dagallier, A.,El-Ahmad, Y.,Guilloteau, J.P.,Guizani, H.,Bouchard, H.,Venot, C.; Discovery of the first non-ATP competitive IGF-1R kinase inhibitors: Advantages in comparison with competitive inhibitors; Bioorg.Med.Chem.Lett., 21:2224-2228, 2011; PubMed: 21441024; DOI: 10.1016/j.bmcl.2011.03.003

実験手法

X-RAY DIFFRACTION (2.1 Å)