3O10

Crystal structure of the HEPN domain from human sacsin

Summary for 3O10

Entry DOI	10.2210/pdb3o10/pdb
Descriptor	Sacsin, MALONATE ION (3 entities in total)
Functional Keywords	all-helical domain, homodimerization, chaperone
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: Q9NZJ4
Total number of polymer chains	4
Total formula weight	64934.13
Authors	Kozlov, G.,Gehring, K. (deposition date: 2010-07-20, release date: 2011-03-30, Last modification date: 2014-07-30)
Primary citation	Kozlov, G.,Denisov, A.Y.,Girard, M.,Dicaire, M.J.,Hamlin, J.,McPherson, P.S.,Brais, B.,Gehring, K. Structural basis of defects in the sacsin HEPN domain responsible for autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS). J.Biol.Chem., 286:20407-20412, 2011 Cited by PubMed: 21507954 DOI: 10.1074/jbc.M111.232884 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation