3O0J
PDE4B In complex with ligand an2898
Summary for 3O0J
Entry DOI | 10.2210/pdb3o0j/pdb |
Descriptor | cAMP-specific 3',5'-cyclic phosphodiesterase 4B, ZINC ION, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | phosphodiesterase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens |
Total number of polymer chains | 1 |
Total formula weight | 38548.01 |
Authors | Alley, M.R.K.,Zhou, Y. (deposition date: 2010-07-19, release date: 2011-08-10, Last modification date: 2024-02-21) |
Primary citation | Freund, Y.R.,Akama, T.,Alley, M.R.,Antunes, J.,Dong, C.,Jarnagin, K.,Kimura, R.,Nieman, J.A.,Maples, K.R.,Plattner, J.J.,Rock, F.,Sharma, R.,Singh, R.,Sanders, V.,Zhou, Y. Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center. Febs Lett., 586:3410-3414, 2012 Cited by PubMed: 22841723DOI: 10.1016/j.febslet.2012.07.058 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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