3NZJ

Crystal structure of yeast 20S proteasome in complex with ligand 2a

3NZJ の概要

• エントリーDOI: 10.2210/pdb3nzj/pdb
• 関連するPDBエントリー: 1JD2 1RYP 3NZW 3NZX
• 関連するBIRD辞書のPRD_ID: PRD_001103
• 分子名称: Proteasome component Y7, Proteasome component C11, Proteasome component PRE2, ... (17 entities in total)
• 機能のキーワード: ubiquitin, protein degradation, n-terminal nucleophilic hydrolase, 19s regulatory particle, ubiquitin-tagged substrates, cytosol, nucleus, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Saccharomyces cerevisiae (brewer's yeast,lager beer yeast,yeast); 詳細
• 細胞内の位置: Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
• タンパク質・核酸の鎖数: 30
• 化学式量合計: 768666.31

構造登録者

Groll, M.,Gallastegui, N.,Marechal, X.,Le Ravalec, V.,Basse, N.,Richy, N.,Genin, E.,Huber, R.,Moroder, M.,Vidal, V.,Reboud-Ravaux, M. (登録日: 2010-07-16, 公開日: 2011-02-16, 最終更新日: 2023-11-22)

• 主引用文献: Groll, M.,Gallastegui, N.,Marechal, X.,Le Ravalec, V.,Basse, N.,Richy, N.,Genin, E.,Huber, R.,Moroder, L.,Vidal, J.,Reboud-Ravaux, M.; 20S proteasome inhibition: designing noncovalent linear peptide mimics of the natural product TMC-95A.; Chemmedchem, 5:1701-1705, 2010; PubMed: 20715286; DOI: 10.1002/cmdc.201000293

実験手法

X-RAY DIFFRACTION (2.4 Å)