3NZ7
A bimolecular anti-parallel-stranded Oxytricha nova telomeric quadruplex in complex with a 3,6-disubstituted acridine ligand containing bis-3-fluoropyrrolidine end side chains
Summary for 3NZ7
Entry DOI | 10.2210/pdb3nz7/pdb |
Related | 1JPQ 1JRN 1L1H 3CE5 3EM2 3EQW 3ERU 3ES0 3ET8 3EUI 3EUM 3NYP |
Descriptor | 5'-D(*GP*GP*GP*GP*TP*TP*TP*TP*GP*GP*GP*G)-3', POTASSIUM ION, 3,6-bis(3-(3'-(S)-fluoropyrrolindino)propionamido)acridine, ... (4 entities in total) |
Functional Keywords | quadruplex, oxtyricha nova, bsu-6039, bsu6039, anti-parallel, bimolecular, macromolecule, dna, g-quadruplex, telomere, acridine, fluorination |
Total number of polymer chains | 2 |
Total formula weight | 8262.88 |
Authors | Campbell, N.H.,Neidle, S. (deposition date: 2010-07-16, release date: 2010-08-25, Last modification date: 2023-09-06) |
Primary citation | Campbell, N.H.,Smith, D.L.,Reszka, A.P.,Neidle, S.,O'Hagan, D. Fluorine in medicinal chemistry: beta-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNA. Org.Biomol.Chem., 9:1328-1331, 2011 Cited by PubMed: 21221451DOI: 10.1039/c0ob00886a PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.1 Å) |
Structure validation
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