3NY9
Crystal structure of the human beta2 adrenergic receptor in complex with a novel inverse agonist
Summary for 3NY9
Entry DOI | 10.2210/pdb3ny9/pdb |
Related | 2RH1 3D4S 3NY8 3NYA |
Descriptor | Beta-2 adrenergic receptor, Lysozyme, CHOLESTEROL, ethyl 4-({(2S)-2-hydroxy-3-[(1-methylethyl)amino]propyl}oxy)-3-methyl-1-benzofuran-2-carboxylate, ... (5 entities in total) |
Functional Keywords | g protein-coupled receptor, lysozyme, fusion, transducer, adrenergic, g-proteins, arrestins, adrenalin, compound 2, glycosylation, palmitoylation, phosphorylation, membrane protein, hydrolase, structural genomics, psi-2, protein structure initiative, accelerated technologies center for gene to 3d structure, atcg3d, gpcr network, gpcr |
Biological source | Homo sapiens More |
Cellular location | Cell membrane ; Multi- pass membrane protein : P07550 |
Total number of polymer chains | 1 |
Total formula weight | 57423.17 |
Authors | Fenalti, G.,Wacker, D.,Brown, M.A.,Katritch, V.,Abagyan, R.,Cherezov, V.,Stevens, R.C.,Accelerated Technologies Center for Gene to 3D Structure (ATCG3D),GPCR Network (GPCR) (deposition date: 2010-07-14, release date: 2010-08-11, Last modification date: 2023-09-06) |
Primary citation | Wacker, D.,Fenalti, G.,Brown, M.A.,Katritch, V.,Abagyan, R.,Cherezov, V.,Stevens, R.C. Conserved Binding Mode of Human beta(2) Adrenergic Receptor Inverse Agonists and Antagonist Revealed by X-ray Crystallography J.Am.Chem.Soc., 132:11443-11445, 2010 Cited by PubMed: 20669948DOI: 10.1021/ja105108q PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.84 Å) |
Structure validation
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