3NY9
Crystal structure of the human beta2 adrenergic receptor in complex with a novel inverse agonist
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Beta-2 adrenergic receptor, Lysozyme | polymer | 490 | 55957.9 | 1 | UniProt (P07550) UniProt (P00720) Pfam (PF00001) Pfam (PF00959) In PDB | Homo sapiens | Beta-2 adrenoreceptor, Beta-2 adrenoceptor, Lysis protein, Muramidase, Endolysin |
2 | A | CHOLESTEROL | non-polymer | 386.7 | 2 | Chemie (CLR) | |||
3 | A | ethyl 4-({(2S)-2-hydroxy-3-[(1-methylethyl)amino]propyl}oxy)-3-methyl-1-benzofuran-2-carboxylate | non-polymer | 335.4 | 1 | Chemie (JSZ) | |||
4 | A | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 1 | Chemie (OLC) | |||
5 | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
A: 1 - 230 (UniProt: P07550)
A: 1002 - 1161 (UniProt: P00720)
A: 263 - 348 (UniProt: P07550)
PDB | External Database | Details |
---|---|---|
Asp -7 | - | expression tag |
Tyr -6 | - | expression tag |
Lys -5 | - | expression tag |
Asp -4 | - | expression tag |
Asp -3 | - | expression tag |
Asp -2 | - | expression tag |
Asp -1 | - | expression tag |
Ala 0 | - | expression tag |
Arg 16 | Gly 16 | variant |
Gln 27 | Glu 27 | variant |
Trp 122 | Glu 122 | engineered mutation |
Glu 187 | Asn 187 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Thr 1054 | Cys 54 | engineered mutation |
Ala 1097 | Cys 97 | engineered mutation |
PDB | External Database | Details |
---|---|---|
His 349 | - | expression tag |
His 350 | - | expression tag |
His 351 | - | expression tag |
His 352 | - | expression tag |
His 353 | - | expression tag |
His 354 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 55957.9 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1465.2 | |
All* | Total formula weight | 57423.2 |