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3NY9

Crystal structure of the human beta2 adrenergic receptor in complex with a novel inverse agonist

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Beta-2 adrenergic receptor, Lysozymepolymer49055957.91UniProt (P07550)
UniProt (P00720)
Pfam (PF00001)
Pfam (PF00959)		Homo sapiensBeta-2 adrenoreceptor, Beta-2 adrenoceptor, Lysis protein, Muramidase, Endolysin
2B, C
(A)		CHOLESTEROLnon-polymer386.72Chemie (CLR)
PubChem (16219173)
PubChem (16758052)
PubChem (304)
PubChem (176980071)
PubChem (40477506)
PubChem (40557614)
PubChem (42579431)
PubChem (42579432)
PubChem (18640088)
PubChem (1715243)
PubChem (1715244)
PubChem (45044259)
PubChem (23423981)
PubChem (49853509)
PubChem (50990013)
PubChem (52934537)
PubChem (56621683)
PubChem (191463)
PubChem (57915018)
PubChem (57939063)
PubChem (58428240)
PubChem (58445498)
PubChem (58663286)
PubChem (368063)
PubChem (369319)
PubChem (44654663)
PubChem (59450329)
PubChem (59628412)
PubChem (59965215)
PubChem (71234641)
PubChem (59993755)
PubChem (60001463)
PubChem (66634651)
PubChem (68055877)
PubChem (68166463)
PubChem (68315613)
PubChem (46937002)
PubChem (70795838)
PubChem (70797612)
PubChem (70954610)
PubChem (70957185)
PubChem (71463909)
PubChem (638019)
PubChem (59274407)
PubChem (1549081)
PubChem (1553803)
PubChem (68311425)
PubChem (68311398)
PubChem (143173313)
PubChem (177156123)
PubChem (89951918)
PubChem (90224410)
PubChem (5997)
PubChem (5283629)
PubChem (5284644)
PubChem (1551269)
PubChem (90070115)
PubChem (91298236)
PubChem (5315842)
PubChem (117965027)
PubChem (6432564)
PubChem (6710666)
PubChem (124146240)
PubChem (7059399)
PubChem (124897607)
PubChem (124896959)
PubChem (6419195)
PubChem (10861996)
PubChem (132837164)
PubChem (101624109)
PubChem (6994560)
PubChem (7055705)
PubChem (7055706)
PubChem (7059398)
PubChem (7059400)
PubChem (7059635)
PubChem (7103033)
PubChem (7182477)
PubChem (7182478)
PubChem (11834483)
PubChem (11888915)
PubChem (11888914)
PubChem (9909206)
PubChem (10045721)
PubChem (71168115)
PubChem (10134774)
PubChem (10293553)
PubChem (71173031)
PubChem (124225449)
PubChem (138967089)
PubChem (11003580)
PubChem (11025495)
PubChem (11058155)
PubChem (139566851)
PubChem (124429284)
PubChem (11463329)
PubChem (11868624)
PubChem (11868625)
PubChem (11869366)
PubChem (11869367)
PubChem (11869368)
PubChem (11869369)
PubChem (12120344)
PubChem (12156156)
PubChem (12303135)
PubChem (12303148)
PubChem (12303156)
PubChem (12303159)
PubChem (12303160)
PubChem (15939944)
PubChem (124909223)
PubChem (124909224)
PubChem (124909225)
PubChem (171828367)
PubChem (173516975)
PubChem (130459183)
PubChem (131992107)
PubChem (139568882)
PubChem (142983773)
PubChem (144054483)
PubChem (144209461)
PubChem (144331236)
PubChem (144808354)
PubChem (145053568)
PubChem (145157652)
PubChem (145215073)
PubChem (145230478)
PubChem (146320991)
PubChem (147857230)
PubChem (154993519)
PubChem (158603858)
PubChem (162906452)
PubChem (162906453)
PubChem (162906454)
PubChem (162906455)
PubChem (162906456)
PubChem (162906457)
PubChem (163255768)
PubChem (163389210)
PubChem (164665303)
PubChem (166553771)
PubChem (166712004)
PubChem (170116175)
PubChem (171764280)
PubChem (171817101)
PubChem (171817104)
PubChem (174285573)
3D
(A)		ethyl 4-({(2S)-2-hydroxy-3-[(1-methylethyl)amino]propyl}oxy)-3-methyl-1-benzofuran-2-carboxylatenon-polymer335.41Chemie (JSZ)
PubChem (489104)
PubChem (913102)
PubChem (913103)
4E
(A)		(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoatenon-polymer356.51Chemie (OLC)
PubChem (25021708)
PubChem (46840179)
PubChem (54294271)
PubChem (54294270)
PubChem (33022)
PubChem (5283468)
PubChem (5364833)
PubChem (11451146)
PubChem (12178130)
5F
(A)		waterwater18.08Chemie (HOH)
Sequence modifications
A: 1 - 230 (UniProt: P07550)
PDBExternal DatabaseDetails
Asp -7-expression tag
Tyr -6-expression tag
Lys -5-expression tag
Asp -4-expression tag
Asp -3-expression tag
Asp -2-expression tag
Asp -1-expression tag
Ala 0-expression tag
Arg 16Gly 16variant
Gln 27Glu 27variant
Trp 122Glu 122engineered mutation
Glu 187Asn 187engineered mutation
A: 1002 - 1161 (UniProt: P00720)
PDBExternal DatabaseDetails
Thr 1054Cys 54engineered mutation
Ala 1097Cys 97engineered mutation
A: 263 - 348 (UniProt: P07550)
PDBExternal DatabaseDetails
His 349-expression tag
His 350-expression tag
His 351-expression tag
His 352-expression tag
His 353-expression tag
His 354-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight55957.9
Non-Polymers*Number of molecules4
Total formula weight1465.2
All*Total formula weight57423.2
*Water molecules are not included.

253091

PDB entries from 2026-05-06

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