3NY9

Crystal structure of the human beta2 adrenergic receptor in complex with a novel inverse agonist

3NY9 の概要

• エントリーDOI: 10.2210/pdb3ny9/pdb
• 関連するPDBエントリー: 2RH1 3D4S 3NY8 3NYA
• 分子名称: Beta-2 adrenergic receptor, Lysozyme, CHOLESTEROL, ethyl 4-({(2S)-2-hydroxy-3-[(1-methylethyl)amino]propyl}oxy)-3-methyl-1-benzofuran-2-carboxylate, ... (5 entities in total)
• 機能のキーワード: g protein-coupled receptor, lysozyme, fusion, transducer, adrenergic, g-proteins, arrestins, adrenalin, compound 2, glycosylation, palmitoylation, phosphorylation, membrane protein, hydrolase, structural genomics, psi-2, protein structure initiative, accelerated technologies center for gene to 3d structure, atcg3d, gpcr network, gpcr
• 由来する生物種: Homo sapiens; 詳細
• 細胞内の位置: Cell membrane ; Multi- pass membrane protein : P07550
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 57423.17

構造登録者

Fenalti, G.,Wacker, D.,Brown, M.A.,Katritch, V.,Abagyan, R.,Cherezov, V.,Stevens, R.C.,Accelerated Technologies Center for Gene to 3D Structure (ATCG3D),GPCR Network (GPCR) (登録日: 2010-07-14, 公開日: 2010-08-11, 最終更新日: 2023-09-06)

• 主引用文献: Wacker, D.,Fenalti, G.,Brown, M.A.,Katritch, V.,Abagyan, R.,Cherezov, V.,Stevens, R.C.; Conserved Binding Mode of Human beta(2) Adrenergic Receptor Inverse Agonists and Antagonist Revealed by X-ray Crystallography; J.Am.Chem.Soc., 132:11443-11445, 2010; PubMed: 20669948; DOI: 10.1021/ja105108q

実験手法