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3NXE

X-ray structure of ester chemical analogue 'covalent dimer' [Ile50,O-Ile50']HIV-1 protease complexed with MVT-101 inhibitor

Summary for 3NXE
Entry DOI10.2210/pdb3nxe/pdb
Related3FSM 3HAU 3HDK 3HLO 3NWQ 3NWX 3NXN 3NYG
Related PRD IDPRD_000398
Descriptorprotease covalent dimer, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide, SULFATE ION, ... (4 entities in total)
Functional Keywordsbeta-barrel, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Total number of polymer chains1
Total formula weight23047.87
Authors
Torbeev, V.Y.,Kent, S.B.H. (deposition date: 2010-07-13, release date: 2011-11-02, Last modification date: 2012-12-12)
Primary citationTorbeev, V.Y.,Raghuraman, H.,Hamelberg, D.,Tonelli, M.,Westler, W.M.,Perozo, E.,Kent, S.B.
Protein conformational dynamics in the mechanism of HIV-1 protease catalysis.
Proc.Natl.Acad.Sci.USA, 108:20982-20987, 2011
Cited by
PubMed: 22158985
DOI: 10.1073/pnas.1111202108
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.61 Å)
Structure validation

217705

數據於2024-03-27公開中

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