3NWM

Crystal structure of a single chain construct composed of MHC class I H-2Kd, beta-2microglobulin and a peptide which is an autoantigen for type 1 diabetes

3NWM の概要

• エントリーDOI: 10.2210/pdb3nwm/pdb
• 関連するPDBエントリー: 1VGK
• 分子名称: Peptide/beta-2microglobulin/MHC class I H-2Kd chimeric protein (2 entities in total)
• 機能のキーワード: mhc class i, h-2kd, peptide-mhc complex, immunoglobulin fold, immune system
• 由来する生物種: Mus musculus (mouse); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 49659.17

構造登録者

Ramagopal, U.A.,Samanta, D.,Nathenson, S.G.,Almo, S.C. (登録日: 2010-07-09, 公開日: 2011-07-06, 最終更新日: 2017-06-28)

• 主引用文献: Samanta, D.,Mukherjee, G.,Ramagopal, U.A.,Chaparro, R.J.,Nathenson, S.G.,DiLorenzo, T.P.,Almo, S.C.; Structural and functional characterization of a single-chain peptide-MHC molecule that modulates both naive and activated CD8+ T cells.; Proc.Natl.Acad.Sci.USA, 108:13682-13687, 2011; PubMed: 21825122; DOI: 10.1073/pnas.1110971108

実験手法

X-RAY DIFFRACTION (2.7 Å)