3NW7
Crystal structure of insulin-like growth factor 1 receptor (IGF-1R-WT) complex with a carbon-linked proline isostere inhibitor (34)
Summary for 3NW7
Entry DOI | 10.2210/pdb3nw7/pdb |
Related | 3NW5 3NW6 |
Descriptor | Insulin-like growth factor 1 receptor, N-({4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}methyl)-6-fluoropyridine-3-carboxamide (3 entities in total) |
Functional Keywords | hormone/growth factor, igf-1r, kinase domain, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P08069 |
Total number of polymer chains | 1 |
Total formula weight | 35433.62 |
Authors | Sack, J.S. (deposition date: 2010-07-09, release date: 2010-07-28, Last modification date: 2024-02-21) |
Primary citation | Sampognaro, A.J.,Wittman, M.D.,Carboni, J.M.,Chang, C.,Greer, A.F.,Hurlburt, W.W.,Sack, J.S.,Vyas, D.M. Proline isosteres in a series of 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitors of IGF-1R kinase and IR kinase. Bioorg.Med.Chem.Lett., 20:5027-5030, 2010 Cited by PubMed: 20675137DOI: 10.1016/j.bmcl.2010.07.045 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.11 Å) |
Structure validation
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