3NW2

Novel nanomolar Imidazopyridines as selective Nitric Oxide Synthase (iNOS) inhibitors: SAR and structural insights

3NW2 の概要

• エントリーDOI: 10.2210/pdb3nw2/pdb
• 関連するPDBエントリー: 1NOD
• 分子名称: Nitric oxide synthase, inducible, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (6 entities in total)
• 機能のキーワード: calmodulin-binding, fad, fmn, iron, metal-binding, nadp, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Mus musculus (mouse)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 100317.49

構造登録者

Graedler, U.,Fuchss, T.,Ulrich, W.R.,Boer, R.,Strub, A.,Hesslinger, C.,Anezo, C.,Diederichs, K.,Zaliani, A. (登録日: 2010-07-09, 公開日: 2011-06-22, 最終更新日: 2023-11-01)

• 主引用文献: Graedler, U.,Fuchss, T.,Ulrich, W.R.,Boer, R.,Strub, A.,Hesslinger, C.,Anezo, C.,Diederichs, K.,Zaliani, A.; Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors: SAR and structural insights; Bioorg.Med.Chem.Lett., 21:4228-4232, 2011; PubMed: 21684157; DOI: 10.1016/j.bmcl.2011.05.073

実験手法

X-RAY DIFFRACTION (2.8 Å)