3NQF

Crystal structure of the mutant L123S of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP

3NQF の概要

• エントリーDOI: 10.2210/pdb3nqf/pdb
• 関連するPDBエントリー: 3G18 3NQ6 3NQ7 3NQA 3NQC 3NQD 3NQE 3NQG 3NQM
• 分子名称: Orotidine 5'-phosphate decarboxylase, 6-HYDROXYURIDINE-5'-PHOSPHATE, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: orotidine 5'-monophosphate decarboxylase, methanobacterium thermoautotrophicum, inhibitor bmp, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• 由来する生物種: Methanothermobacter thermautotrophicus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 50489.69

構造登録者

Fedorov, A.A.,Fedorov, E.V.,Wood, B.M.,Gerlt, J.A.,Almo, S.C. (登録日: 2010-06-29, 公開日: 2011-05-11, 最終更新日: 2023-09-06)

• 主引用文献: Iiams, V.,Desai, B.J.,Fedorov, A.A.,Fedorov, E.V.,Almo, S.C.,Gerlt, J.A.; Mechanism of the orotidine 5'-monophosphate decarboxylase-catalyzed reaction: importance of residues in the orotate binding site.; Biochemistry, 50:8497-8507, 2011; PubMed: 21870810; DOI: 10.1021/bi2012355

実験手法

X-RAY DIFFRACTION (1.312 Å)