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3NOA

Crystal structure of human PPAR-gamma ligand binding domain complex with a potency improved agonist

Summary for 3NOA
Entry DOI10.2210/pdb3noa/pdb
DescriptorPeroxisome proliferator-activated receptor gamma, (5-{3-[4-(biphenyl-4-ylcarbonyl)-2-propylphenoxy]propoxy}-1H-indol-1-yl)acetic acid (3 entities in total)
Functional Keywordshypoglycemic agents, models, molecular, ppar alpha, ppar gamma, protein isoforms, quinolines, structure-activity relationship, thiazolidinediones, transcription
Biological sourceHomo sapiens (human)
Cellular locationNucleus: P37231
Total number of polymer chains2
Total formula weight63089.32
Authors
Peng, Y.H.,Wu, J.S.,Wu, S.Y. (deposition date: 2010-06-25, release date: 2011-06-29, Last modification date: 2023-11-01)
Primary citationPeng, Y.H.,Coumar, M.S.,Leou, J.S.,Wu, J.S.,Shiao, H.Y.,Lin, C.H.,Lyu, P.C.,Hsieh, H.P.,Wu, S.Y.
Crystal structure of human PPAR-gamma ligand binding domain complex with a potency improved agonist
To be published,
Experimental method
X-RAY DIFFRACTION (1.98 Å)
Structure validation

217705

건을2024-03-27부터공개중

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