3NMQ

Hsp90b N-terminal domain in complex with EC44, a pyrrolo-pyrimidine methoxypyridine inhibitor

3NMQ の概要

• エントリーDOI: 10.2210/pdb3nmq/pdb
• 分子名称: Heat shock protein HSP 90-beta, 5-{2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}-2-methylpent-4-yn-2 -ol (3 entities in total)
• 機能のキーワード: atpase, chaperone-chaperone inhibitor complex, chaperone/chaperone inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P08238
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 27100.02

構造登録者

Arndt, J.W.,Yun, T.J.,Harning, E.K.,Giza, K.,Rabah, D.,Li, P.,Luchetti, D.,Shi, J.,Manning, A.,Kehry, M.R. (登録日: 2010-06-22, 公開日: 2010-12-22, 最終更新日: 2024-03-13)

• 主引用文献: Yun, T.J.,Harning, E.K.,Giza, K.,Rabah, D.,Li, P.,Arndt, J.W.,Luchetti, D.,Biamonte, M.A.,Shi, J.,Lundgren, K.,Manning, A.,Kehry, M.R.; EC144, a Synthetic Inhibitor of Heat Shock Protein 90, Blocks Innate and Adaptive Immune Responses in Models of Inflammation and Autoimmunity.; J.Immunol., 186:563-575, 2011; PubMed: 21131419; DOI: 10.4049/jimmunol.1000222

実験手法

X-RAY DIFFRACTION (2.2 Å)