3NLX
Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(((3R,4R)-4-(2- (2,2-Difluoro-2-(3-fluorophenyl)ethylamino)ethoxy)pyrrolidin-3-yl)methyl)-4-methylpyridin-2-amine
Summary for 3NLX
Entry DOI | 10.2210/pdb3nlx/pdb |
Related | 3NLD 3NLE 3NLF 3NLG 3NLH 3NLI 3NLJ 3NLK 3NLM 3NLN 3NLO 3NLP 3NLQ 3NLR 3NLT 3NLU 3NLV 3NLW 3NLY 3NLZ 3NM0 3NNY 3NNZ |
Descriptor | Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total) |
Functional Keywords | nitric oxide synthase, heme thiolate enzyme, inhibitor, oxidoreductase |
Biological source | Rattus norvegicus (brown rat,rat,rats) |
Cellular location | Cell membrane, sarcolemma ; Peripheral membrane protein : P29476 |
Total number of polymer chains | 2 |
Total formula weight | 100340.94 |
Authors | Li, H.,Delker, S.L.,Poulos, T.L. (deposition date: 2010-06-21, release date: 2011-01-19, Last modification date: 2023-09-06) |
Primary citation | Xue, F.,Li, H.,Delker, S.L.,Fang, J.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B. Potent, highly selective, and orally bioavailable gem-difluorinated monocationic inhibitors of neuronal nitric oxide synthase. J.Am.Chem.Soc., 132:14229-14238, 2010 Cited by PubMed: 20843082DOI: 10.1021/ja106175q PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.87 Å) |
Structure validation
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