3NLU
Structure of endothelial nitric oxide synthase heme domain complexed with N1-{(3'R,4'R)-4'-[(6"-amino-4"-methylpyridin-2"-yl)methyl]pyrrolidin-3'-yl}-N2-(3'-fluorophenethyl)ethane-1,2-diamine tetrahydrochloride
Summary for 3NLU
Entry DOI | 10.2210/pdb3nlu/pdb |
Related | 3NLD 3NLE 3NLF 3NLG 3NLH 3NLI 3NLJ 3NLK 3NLM 3NLN 3NLO 3NLP 3NLQ 3NLR 3NLT 3NLV 3NLW 3NLX 3NLY 3NLZ 3NM0 3NNY 3NNZ |
Descriptor | Nitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (9 entities in total) |
Functional Keywords | nitric oxide synthase, heme enzyme, substrate inhibitor, oxidoreductase |
Biological source | Bos taurus (bovine,cow,domestic cattle,domestic cow) |
Total number of polymer chains | 2 |
Total formula weight | 102537.23 |
Authors | Xue, F.,Li, H.,Fang, J.,Delker, S.L.,Poulos, T.L.,Silverman, R.B. (deposition date: 2010-06-21, release date: 2011-01-19, Last modification date: 2024-02-21) |
Primary citation | Xue, F.,Li, H.,Delker, S.L.,Fang, J.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B. Potent, highly selective, and orally bioavailable gem-difluorinated monocationic inhibitors of neuronal nitric oxide synthase. J.Am.Chem.Soc., 132:14229-14238, 2010 Cited by PubMed: 20843082DOI: 10.1021/ja106175q PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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