3NJ8
Crystal structure of T. gondii enoyl acyl carrier protein reductase with bound triclosan like inhibitor
Summary for 3NJ8
Entry DOI | 10.2210/pdb3nj8/pdb |
Related | 2O2S 2O2Y 2O50 |
Descriptor | Enoyl-acyl carrier reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 3-chloro-4-(2-hydroxy-4-propylphenoxy)benzonitrile, ... (4 entities in total) |
Functional Keywords | enoyl reductase, enr triclosan, rossmann nad binding fold, nadh binding, oxidoreductase |
Biological source | Toxoplasma gondii |
Total number of polymer chains | 2 |
Total formula weight | 68685.44 |
Authors | Muench, S.P.,Ruzheinikov, S.N.,Rice, D.W. (deposition date: 2010-06-17, release date: 2010-09-29, Last modification date: 2024-02-21) |
Primary citation | Tipparaju, S.K.,Muench, S.P.,Mui, E.J.,Ruzheinikov, S.N.,Lu, J.Z.,Hutson, S.L.,Kirisits, M.J.,Prigge, S.T.,Roberts, C.W.,Henriquez, F.L.,Kozikowski, A.P.,Rice, D.W.,McLeod, R.L. Identification and development of novel inhibitors of Toxoplasma gondii enoyl reductase. J.Med.Chem., 53:6287-6300, 2010 Cited by PubMed: 20698542DOI: 10.1021/jm9017724 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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