3NJ8

Crystal structure of T. gondii enoyl acyl carrier protein reductase with bound triclosan like inhibitor

3NJ8 の概要

• エントリーDOI: 10.2210/pdb3nj8/pdb
• 関連するPDBエントリー: 2O2S 2O2Y 2O50
• 分子名称: Enoyl-acyl carrier reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 3-chloro-4-(2-hydroxy-4-propylphenoxy)benzonitrile, ... (4 entities in total)
• 機能のキーワード: enoyl reductase, enr triclosan, rossmann nad binding fold, nadh binding, oxidoreductase
• 由来する生物種: Toxoplasma gondii
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 68685.44

構造登録者

Muench, S.P.,Ruzheinikov, S.N.,Rice, D.W. (登録日: 2010-06-17, 公開日: 2010-09-29, 最終更新日: 2024-02-21)

• 主引用文献: Tipparaju, S.K.,Muench, S.P.,Mui, E.J.,Ruzheinikov, S.N.,Lu, J.Z.,Hutson, S.L.,Kirisits, M.J.,Prigge, S.T.,Roberts, C.W.,Henriquez, F.L.,Kozikowski, A.P.,Rice, D.W.,McLeod, R.L.; Identification and development of novel inhibitors of Toxoplasma gondii enoyl reductase.; J.Med.Chem., 53:6287-6300, 2010; PubMed: 20698542; DOI: 10.1021/jm9017724

実験手法

X-RAY DIFFRACTION (2.7 Å)