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3NHD

GYVLGS segment 127-132 from human prion with V129

3NHD の概要
エントリーDOI10.2210/pdb3nhd/pdb
関連するPDBエントリー3NHC
分子名称Major prion protein, ACETIC ACID (3 entities in total)
機能のキーワードamyloid-like protofibril, protein fibril
由来する生物種Homo sapiens (human)
細胞内の位置Cell membrane; Lipid-anchor, GPI-anchor. Isoform 2: Cytoplasm: P04156
タンパク質・核酸の鎖数2
化学式量合計1309.42
構造登録者
Apostol, M.I.,Eisenberg, D. (登録日: 2010-06-14, 公開日: 2010-08-04, 最終更新日: 2024-05-22)
主引用文献Apostol, M.I.,Sawaya, M.R.,Cascio, D.,Eisenberg, D.
Crystallographic studies of prion protein (PrP) segments suggest how structural changes encoded by polymorphism at residue 129 modulate susceptibility to human prion disease.
J.Biol.Chem., 285:29671-29675, 2010
Cited by
PubMed Abstract: A single nucleotide polymorphism (SNP) in codon 129 of the human prion gene, leading to a change from methionine to valine at residue 129 of prion protein (PrP), has been shown to be a determinant in the susceptibility to prion disease. However, the molecular basis of this effect remains unexplained. In the current study, we determined crystal structures of prion segments having either Met or Val at residue 129. These 6-residue segments of PrP centered on residue 129 are "steric zippers," pairs of interacting β-sheets. Both structures of these "homozygous steric zippers" reveal direct intermolecular interactions between Met or Val in one sheet and the identical residue in the mating sheet. These two structures, plus a structure-based model of the heterozygous Met-Val steric zipper, suggest an explanation for the previously observed effects of this locus on prion disease susceptibility and progression.
PubMed: 20685658
DOI: 10.1074/jbc.C110.158303
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (1.92 Å)
構造検証レポート
Validation report summary of 3nhd
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-11-20に公開中

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