Crystal structure of the human CNOT6L nuclease domain

Summary for 3NGQ

Related3NGN 3NGO
DescriptorCCR4-NOT transcription complex subunit 6-like, 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE, MAGNESIUM ION, ... (4 entities in total)
Functional Keywordsalpha/beta sandwich fold, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm Q96LI5
Total number of polymer chains1
Total molecular weight45406.31
Wang, H.,Morita, M.,Yang, W.,Bartlam, M.,Yamamoto, T.,Rao, Z. (deposition date: 2010-06-13, release date: 2010-07-28, Last modification date: 2011-07-13)
Primary citation
Wang, H.,Morita, M.,Yang, X.,Suzuki, T.,Yang, W.,Wang, J.,Ito, K.,Wang, Q.,Zhao, C.,Bartlam, M.,Yamamoto, T.,Rao, Z.
Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity.
Embo J., 2010
PubMed: 20628353 (PDB entries with the same primary citation)
DOI: 10.1038/emboj.2010.152
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.253100.6%7.3%5.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution