3NG5
Crystal Structure of V30M transthyretin complexed with (-)-epigallocatechin gallate (EGCG)
Summary for 3NG5
Entry DOI | 10.2210/pdb3ng5/pdb |
Descriptor | Transthyretin, (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate, GLYCEROL, ... (4 entities in total) |
Functional Keywords | retinol-binding, secreted, thyroid hormone, transport, vitamin a, transport protein, thyroxine |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P02766 |
Total number of polymer chains | 2 |
Total formula weight | 29086.06 |
Authors | Miyata, M.,Nakamura, T.,Ikemizu, S.,Chirifu, M.,Yamagata, Y.,Kai, H. (deposition date: 2010-06-11, release date: 2010-07-07, Last modification date: 2023-11-01) |
Primary citation | Miyata, M.,Sato, T.,Kugimiya, M.,Sho, M.,Nakamura, T.,Ikemizu, S.,Chirifu, M.,Mizuguchi, M.,Nabeshima, Y.,Suwa, Y.,Morioka, H.,Arimori, T.,Suico, M.A.,Shuto, T.,Sako, Y.,Momohara, M.,Koga, T.,Morino-Koga, S.,Yamagata, Y.,Kai, H. Crystal structure of green tea polyphenol(-)-epigallocatechin gallate (EGCG)-transthyretin complex reveals novel binding site distinct from thyroxine binding site Biochemistry, 2010 Cited by PubMed: 20565072DOI: 10.1021/bi1004409 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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