3NFP

Crystal structure of the Fab fragment of therapeutic antibody daclizumab in complex with IL-2Ra (CD25) ectodomain

Summary for 3NFP

• Entry DOI: 10.2210/pdb3nfp/pdb
• Related: 3IU3 3NFS
• Descriptor: Heavy chain of Fab fragment of daclizumab, Light chain of Fab fragment of daclizumab, Interleukin-2 receptor subunit alpha, ... (4 entities in total)
• Functional Keywords: il-2ra, cd25, daclizumab, zenapax, therapeutic antibody, immune system, immune system-cytokine complex, immune system/cytokine
• Biological source: Homo sapiens (human); More
• Cellular location: Membrane; Single-pass type I membrane protein: P01589
• Total number of polymer chains: 6
• Total formula weight: 143115.39

Authors

Yang, H.,Wang, J.,Du, J.,Zhong, C.,Guo, Y.,Ding, J. (deposition date: 2010-06-10, release date: 2010-09-15, Last modification date: 2023-11-01)

• Primary citation: Yang, H.,Wang, J.,Du, J.,Zhong, C.,Zhang, D.,Guo, H.,Guo, Y.,Ding, J.; Structural basis of immunosuppression by the therapeutic antibody daclizumab; Cell Res., 20:1361-1371, 2010; PubMed: 20820193; DOI: 10.1038/cr.2010.130

Experimental method

X-RAY DIFFRACTION (2.86 Å)