3NFP

Crystal structure of the Fab fragment of therapeutic antibody daclizumab in complex with IL-2Ra (CD25) ectodomain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, H)	Heavy chain of Fab fragment of daclizumab	polymer	216	23034.7	2		Homo sapiens (human)
2	B, D (B, L)	Light chain of Fab fragment of daclizumab	polymer	212	23134.7	2		Homo sapiens (human)
3	E, F (I, K)	Interleukin-2 receptor subunit alpha	polymer	223	25388.3	2	UniProt (P01589) Pfam (PF00084)	Homo sapiens (human)	IL-2 receptor subunit alpha, IL-2R subunit alpha, IL-2-RA, IL2-RA, p55, TAC antigen, CD_antigen=CD25
4	G, H, I, J, K... (A, B, H, L, I...)	water	water		18.0	97	Chemie (HOH)

Sequence modifications

I, K: 1 - 217 (UniProt: P01589)

PDB	External Database	Details
His 218	-	expression tag
His 219	-	expression tag
His 220	-	expression tag
His 221	-	expression tag
His 222	-	expression tag
His 223	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	143115.4
All*	Total formula weight	143115.4

*Water molecules are not included.