3NF6

Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design

Summary for 3NF6

Entry DOI	10.2210/pdb3nf6/pdb
Related	1bhl 1bi4 1biu 1ex4 1k6y 3NF7 3NF8 3NF9 3NFA
Descriptor	Integrase, SULFATE ION, 1,2-ETHANEDIOL, ... (7 entities in total)
Functional Keywords	integrase, integration, dna, see mutations, intra-cellular, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	2
Total formula weight	42158.03
Authors	Peat, T.S.,Newman, J.,Deadman, J.J.,Rhodes, D. (deposition date: 2010-06-09, release date: 2011-04-27, Last modification date: 2024-03-20)
Primary citation	Rhodes, D.I.,Peat, T.S.,Vandegraaff, N.,Jeevarajah, D.,Le, G.,Jones, E.D.,Smith, J.A.,Coates, J.A.,Winfield, L.J.,Thienthong, N.,Newman, J.,Lucent, D.,Ryan, J.H.,Savage, G.P.,Francis, C.L.,Deadman, J.J. Structural basis for a new mechanism of inhibition of HIV-1 integrase identified by fragment screening and structure-based design ANTIVIR.CHEM.CHEMOTHER., 21:155-168, 2011 Cited by PubMed Abstract: HIV-1 integrase is a clinically validated therapeutic target for the treatment of HIV-1 infection, with one approved therapeutic currently on the market. This enzyme represents an attractive target for the development of new inhibitors to HIV-1 that are effective against the current resistance mutations. PubMed: 21602613 DOI: 10.3851/IMP1716 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation