3NF6

Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design

3NF6 の概要

• エントリーDOI: 10.2210/pdb3nf6/pdb
• 関連するPDBエントリー: 1bhl 1bi4 1biu 1ex4 1k6y 3NF7 3NF8 3NF9 3NFA
• 分子名称: Integrase, SULFATE ION, 1,2-ETHANEDIOL, ... (7 entities in total)
• 機能のキーワード: integrase, integration, dna, see mutations, intra-cellular, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 42158.03

構造登録者

Peat, T.S.,Newman, J.,Deadman, J.J.,Rhodes, D. (登録日: 2010-06-09, 公開日: 2011-04-27, 最終更新日: 2024-03-20)

• 主引用文献: Rhodes, D.I.,Peat, T.S.,Vandegraaff, N.,Jeevarajah, D.,Le, G.,Jones, E.D.,Smith, J.A.,Coates, J.A.,Winfield, L.J.,Thienthong, N.,Newman, J.,Lucent, D.,Ryan, J.H.,Savage, G.P.,Francis, C.L.,Deadman, J.J.; Structural basis for a new mechanism of inhibition of HIV-1 integrase identified by fragment screening and structure-based design; ANTIVIR.CHEM.CHEMOTHER., 21:155-168, 2011; PubMed: 21602613; DOI: 10.3851/IMP1716

実験手法

X-RAY DIFFRACTION (1.9 Å)