3NAL

SR Ca(2+)-ATPase in the HnE2 state complexed with the Thapsigargin derivative DTB

3NAL の概要

• エントリーDOI: 10.2210/pdb3nal/pdb
• 関連するPDBエントリー: 2BY4 2C8K 3NAM 3NAN
• 分子名称: SERCA1a, POTASSIUM ION, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: serca, p-type atpase, ca2+-atpase, thapsigargin, prostate cancer, calcium transport, endoplasmic reticulum, hydrolase, ion transport, sarcoplasmic reticulum, transmembrane, transport
• 由来する生物種: Oryctolagus cuniculus (rabbit)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 110286.75

構造登録者

Winther, A.M.L.,Sonntag, Y.,Olesen, C.,Moller, J.V.,Nissen, P. (登録日: 2010-06-02, 公開日: 2010-06-30, 最終更新日: 2023-11-01)

• 主引用文献: Winther, A.M.L.,Liu, H.,Sonntag, Y.,Olesen, C.,le Maire, M.,Soehoel, H.,Olsen, C.E.,Christensen, S.B.,Nissen, P.,Moller, J.V.; Critical roles of hydrophobicity and orientation of side chains for inactivation of sarcoplasmic reticulum Ca2+-ATPase with thapsigargin and thapsigargin analogs; J.Biol.Chem., 285:28883-28892, 2010; PubMed: 20551329; DOI: 10.1074/jbc.M110.136242

実験手法

X-RAY DIFFRACTION (2.65 Å)