3NA0

Crystal structure of human CYP11A1 in complex with 20,22-dihydroxycholesterol

3NA0 の概要

• エントリーDOI: 10.2210/pdb3na0/pdb
• 関連するPDBエントリー: 3N9Y 3N9Z 3NA1
• 分子名称: Cholesterol side-chain cleavage enzyme, mitochondrial, Adrenodoxin, mitochondrial, PROTOPORPHYRIN IX CONTAINING FE, ... (6 entities in total)
• 機能のキーワード: cytochrome p450, 20, 22-dihydroxycholesterol, side chain cleavage, structural genomics, structural genomics consortium, sgc, oxidoreductase, electron transport
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Mitochondrion membrane: P05108; Mitochondrion matrix : P10109
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 127276.72

構造登録者

Strushkevich, N.V.,MacKenzie, F.,Tempel, W.,Botchkarev, A.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Weigelt, J.U.,Park, H.,Structural Genomics Consortium (SGC) (登録日: 2010-05-31, 公開日: 2010-09-08, 最終更新日: 2024-02-21)

• 主引用文献: Strushkevich, N.,Mackenzie, F.,Cherkesova, T.,Grabovec, I.,Usanov, S.,Park, H.W.; Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system.; Proc.Natl.Acad.Sci.USA, 108:10139-10143, 2011; PubMed: 21636783; DOI: 10.1073/pnas.1019441108

実験手法

X-RAY DIFFRACTION (2.5 Å)