3N8W

Crystal Structure of R120Q/Native Cyclooxygenase-1 Heterodimer mutant in complex with Flurbiprofen

3N8W の概要

• エントリーDOI: 10.2210/pdb3n8w/pdb
• 関連するPDBエントリー: 3N8V 3N8X 3N8Y 3N8Z
• 分子名称: Prostaglandin G/H synthase 1, octyl beta-D-glucopyranoside, 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
• 機能のキーワード: cox-1, cyclooxygenase, peroxidase, prostaglandin, heme, flurbiprofen, merohedral twinned, heterodimer mutant, oxidoreductase
• 由来する生物種: Ovis aries (sheep); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 133292.81

構造登録者

Sidhu, R.S. (登録日: 2010-05-28, 公開日: 2010-07-28, 最終更新日: 2023-09-06)

• 主引用文献: Sidhu, R.S.,Lee, J.Y.,Yuan, C.,Smith, W.L.; Comparison of Cyclooxygenase-1 Crystal Structures: Cross-Talk between Monomers Comprising Cyclooxygenase-1 Homodimers; Biochemistry, 49:7069-7079, 2010; PubMed: 20669977; DOI: 10.1021/bi1003298

実験手法

X-RAY DIFFRACTION (2.75 Å)