3N8K

Type II dehydroquinase from Mycobacterium tuberculosis complexed with citrazinic acid

3N8K の概要

• エントリーDOI: 10.2210/pdb3n8k/pdb
• 関連するPDBエントリー: 1h05 1h0r 1h0s 2dhq 3N59
• 分子名称: 3-dehydroquinate dehydratase, 2,6-dioxo-1,2,3,6-tetrahydropyridine-4-carboxylic acid, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: dehydratase, shikimate pathway, lyase, aromatic amino acid biosynthesis, tuberculosis, drug target, citrazinic acid, structural genomics, tb structural genomics consortium, tbsgc
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 24
• 化学式量合計: 451932.88

構造登録者

Snee, W.C.,Palaninathan, S.K.,Sacchettini, J.C.,Dias, M.V.B.,Bromfield, K.M.,Payne, R.,Ciulli, A.,Howard, N.I.,Abell, C.,Blundell, T.L.,TB Structural Genomics Consortium (TBSGC) (登録日: 2010-05-28, 公開日: 2010-07-21, 最終更新日: 2023-09-06)

• 主引用文献: Dias, M.V.,Snee, W.C.,Bromfield, K.M.,Payne, R.J.,Palaninathan, S.K.,Ciulli, A.,Howard, N.I.,Abell, C.,Sacchettini, J.C.,Blundell, T.L.; Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis.; Biochem.J., 436:729-739, 2011; PubMed: 21410435; DOI: 10.1042/BJ20110002

実験手法

X-RAY DIFFRACTION (2.25 Å)