3N7S
Crystal structure of the ectodomain complex of the CGRP receptor, a Class-B GPCR, reveals the site of drug antagonism
Summary for 3N7S
Entry DOI | 10.2210/pdb3n7s/pdb |
Related | 3N7P 3N7R |
Descriptor | Calcitonin gene-related peptide type 1 receptor, Receptor activity-modifying protein 1, N-{(1S)-5-amino-1-[(4-pyridin-4-ylpiperazin-1-yl)carbonyl]pentyl}-3,5-dibromo-Nalpha-{[4-(2-oxo-1,4-dihydroquinazolin-3 (2H)-yl)piperidin-1-yl]carbonyl}-D-tyrosinamide, ... (6 entities in total) |
Functional Keywords | gpcr, class b gpcr, antagonist, olcegepant, telcagepant, migraine, membrane protein |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane; Multi-pass membrane protein: Q16602 Membrane; Single-pass type I membrane protein: O60894 |
Total number of polymer chains | 4 |
Total formula weight | 50180.49 |
Authors | Ter Haar, E. (deposition date: 2010-05-27, release date: 2010-09-15, Last modification date: 2022-10-26) |
Primary citation | Ter Haar, E.,Koth, C.M.,Abdul-Manan, N.,Swenson, L.,Coll, J.T.,Lippke, J.A.,Lepre, C.A.,Garcia-Guzman, M.,Moore, J.M. Crystal Structure of the Ectodomain Complex of the CGRP Receptor, a Class-B GPCR, Reveals the Site of Drug Antagonism. Structure, 18:1083-1093, 2010 Cited by PubMed: 20826335DOI: 10.1016/j.str.2010.05.014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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