3N5V

Structure of neuronal nitric oxide synthase heme domain in complex with 4-(3-(2-(6-amino-4-methylpyridin-2-yl)ethyl)phenethyl)-6-methylpyridin-2-amine

3N5V の概要

• エントリーDOI: 10.2210/pdb3n5v/pdb
• 関連するPDBエントリー: 3N5P 3N5Q 3N5R 3N5S 3N5T 3N5W 3N5X 3N5Y 3N5Z 3N60 3N61 3N62 3N63 3N64 3N65 3N66 3N67 3N68 3N69 3N6A 3N6B 3N6C 3N6D 3N6E 3N6F 3N6G
• 分子名称: Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
• 機能のキーワード: heme enzyme, nitric oxide synthase, substrate inhibitor, zn binding', oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Rattus norvegicus (rat)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 100216.96

構造登録者

Li, H.,Delker, S.L.,Poulos, T.L. (登録日: 2010-05-25, 公開日: 2011-02-09, 最終更新日: 2023-09-06)

• 主引用文献: Delker, S.L.,Xue, F.,Li, H.,Jamal, J.,Silverman, R.B.,Poulos, T.L.; Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .; Biochemistry, 49:10803-10810, 2010; PubMed: 21138269; DOI: 10.1021/bi1013479

実験手法

X-RAY DIFFRACTION (2.3 Å)