3N25

The structure of muscle pyruvate kinase in complex with proline, pyruvate, and Mn2+

3N25 の概要

• エントリーDOI: 10.2210/pdb3n25/pdb
• 分子名称: Pyruvate kinase isozymes M1/M2, PROLINE, MANGANESE (II) ION, ... (9 entities in total)
• 機能のキーワード: pyruvate kinase, glycolysis, allosteric regulation, transferase
• 由来する生物種: Oryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits)
• 細胞内の位置: Cytoplasm : P11974
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 470150.38

構造登録者

Fenton, A.W.,Johnson, T.A.,Holyoak, T. (登録日: 2010-05-17, 公開日: 2010-07-28, 最終更新日: 2023-11-15)

• 主引用文献: Fenton, A.W.,Johnson, T.A.,Holyoak, T.; The pyruvate kinase model system, a cautionary tale for the use of osmolyte perturbations to support conformational equilibria in allostery.; Protein Sci., 19:1796-1800, 2010; PubMed: 20629175; DOI: 10.1002/pro.450

実験手法

X-RAY DIFFRACTION (2.41 Å)