3MYQ

Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-5-[(1H-imidazo[4,5-c]quinolin-2-ylsulfanyl)acetyl]benzenesulfonamide

Summary for 3MYQ

Entry DOI	10.2210/pdb3myq/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (6 entities in total)
Functional Keywords	drug design, carbonic anhydrase, benzenesulfonamide, lyase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P00918
Total number of polymer chains	1
Total formula weight	30138.88
Authors	Grazulis, S.,Manakova, E.,Golovenko, D. (deposition date: 2010-05-11, release date: 2011-02-02, Last modification date: 2023-09-06)
Primary citation	Baranauskiene, L.,Golovenko, D.,Manakova, E.,Grazulis, S.,Tumkevicius, S.,Matulis, D. Indapamide-like benzenesulfonamides as inhibitors of carbonic anhydrases I, II, VII, and XIII. Bioorg.Med.Chem., 18:7357-7364, 2010 Cited by PubMed: 20926301 DOI: 10.1016/j.bmc.2010.09.016 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.35 Å)

Structure validation