3MYC

Crystal Structure of HP67 H41F - P212121

3MYC の概要

• エントリーDOI: 10.2210/pdb3myc/pdb
• 関連するPDBエントリー: 1YU5 2K6M 2K6N 2RJX 2RJY 3MYA 3mye
• 分子名称: Villin-1 (2 entities in total)
• 機能のキーワード: protein, helix, hydrogen bond, structural protein
• 由来する生物種: Gallus gallus (bantam,chickens)
• 細胞内の位置: Cytoplasm, cytoskeleton: P02640
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 7620.69

構造登録者

Brown, J.W.,Farelli, J.D.,McKnight, C.J. (登録日: 2010-05-10, 公開日: 2011-05-25, 最終更新日: 2024-02-28)

主引用文献

Brown, J.W.,Farelli, J.D.,McKnight, C.J.
On unsatisfied hydrogen bonds in the N-terminal subdomain of villin headpiece.
J.Mol.Biol., 413:543-547, 2011

PubMed Abstract: Villin headpiece is a small autonomously folding protein that has emerged as a model system for understanding the fundamental tenets governing protein folding. In this communication, we employ NMR and X-ray crystallography to characterize a point mutant, H41F, which retains actin-binding activity, is more thermostable but, interestingly, does not exhibit the partially folded intermediate observed of either wild-type or other similar point mutants.

PubMed: 21903098
DOI: 10.1016/j.jmb.2011.08.024

実験手法

X-RAY DIFFRACTION (1.7 Å)