3MXY

Structures of Grb2-SH2 Domain and AICD peptide Complexes Reveal a Conformational Switch and Their Functional Implications.

Summary for 3MXY

• Entry DOI: 10.2210/pdb3mxy/pdb
• Related: 1JYQ 1JYR 3KFJ 3MXC
• Descriptor: Growth factor receptor-bound protein 2, AICD peptide E683V variant (3 entities in total)
• Functional Keywords: protein-peptide complex, aicd, grb2-sh2, protein binding, alzheimer's disease, app
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P62993
• Total number of polymer chains: 2
• Total formula weight: 12864.38

Authors

Sen, U.,Das, S. (deposition date: 2010-05-08, release date: 2011-05-11, Last modification date: 2023-11-22)

• Primary citation: Das, S.,Raychaudhuri, M.,Sen, U.,Mukhopadhyay, D.; Functional Implications of the Conformational Switch in AICD Peptide upon Binding to Grb2-SH2 Domain.; J.Mol.Biol., 414:217-230, 2011; PubMed: 22001015; DOI: 10.1016/j.jmb.2011.09.046

Experimental method

X-RAY DIFFRACTION (2.3 Å)