3MXY
Structures of Grb2-SH2 Domain and AICD peptide Complexes Reveal a Conformational Switch and Their Functional Implications.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Growth factor receptor-bound protein 2 | polymer | 101 | 11729.3 | 1 | UniProt (P62993) Pfam (PF00017) In PDB | Homo sapiens (human) | Adapter protein GRB2, SH2/SH3 adapter GRB2, Protein Ash |
| 2 | L | AICD peptide E683V variant | polymer | 9 | 1135.1 | 1 | UniProt (by SIFTS) (P05067) In PDB | ||
| 3 | water | water | 18.0 | 122 | Chemie (HOH) |
Sequence modifications
A: 55 - 152 (UniProt: P62993)
| PDB | External Database | Details |
|---|---|---|
| Gly 52 | - | expression tag |
| Ser 53 | - | expression tag |
| His 54 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 12864.4 | |
| All* | Total formula weight | 12864.4 |
