3MUU

Crystal structure of the Sindbis virus E2-E1 heterodimer at low pH

Summary for 3MUU

• Entry DOI: 10.2210/pdb3muu/pdb
• Descriptor: Structural polyprotein, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: beta barrels, ig-like folds, viral protein
• Biological source: Sindbis virus (SINV); More
• Cellular location: Capsid protein: Virion . p62: Virion membrane ; Single- pass type I membrane protein . E2 envelope glycoprotein: Virion membrane ; Single-pass type I membrane protein . E1 envelope glycoprotein: Virion membrane ; Single-pass type I membrane protein . 6K protein: Host cell membrane ; Multi-pass membrane protein : P03316
• Total number of polymer chains: 6
• Total formula weight: 505014.78

Authors

Li, L.,Jose, J.,Xiang, Y.,Kuhn, R.J.,Rossmann, M.G. (deposition date: 2010-05-03, release date: 2010-11-24, Last modification date: 2020-07-29)

• Primary citation: Li, L.,Jose, J.,Xiang, Y.,Kuhn, R.J.,Rossmann, M.G.; Structural changes of envelope proteins during alphavirus fusion.; Nature, 468:705-708, 2010; PubMed: 21124457; DOI: 10.1038/nature09546

Experimental method

X-RAY DIFFRACTION (3.29 Å)