3MTC

Crystal Structure of INPP5B in complex with phosphatidylinositol 4-phosphate

3MTC の概要

• エントリーDOI: 10.2210/pdb3mtc/pdb
• 関連するPDBエントリー: 3N9V 3NR8
• 分子名称: Type II inositol-1,4,5-trisphosphate 5-phosphatase, GLYCEROL, MAGNESIUM ION, ... (7 entities in total)
• 機能のキーワード: inpp5ba, phosphoinositide 5-phosphatase, inositol signalling, phosphatase, magnesium, structural genomics, sgc, sgc stockholm, structural genomics consortium, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm, cytosol: P32019
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37207.68

構造登録者

Tresaugues, L.,Welin, M.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Collins, R.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, I.,Karlberg, T.,Kol, S.,Kotenyova, T.,Moche, M.,Nyman, T.,Persson, C.,Schuler, H.,Schutz, P.,Siponen, M.I.,Thorsell, A.G.,van der Berg, S.,Wahlberg, E.,Weigelt, J.,Wisniewska, M.,Nordlund, P.,Structural Genomics Consortium (SGC) (登録日: 2010-04-30, 公開日: 2010-06-30, 最終更新日: 2023-09-06)

• 主引用文献: Tresaugues, L.,Silvander, C.,Flodin, S.,Welin, M.,Nyman, T.,Graslund, S.,Hammarstrom, M.,Berglund, H.,Nordlund, P.; Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases; Structure, 22:744-755, 2014; PubMed: 24704254; DOI: 10.1016/j.str.2014.01.013

実験手法

X-RAY DIFFRACTION (2.4 Å)