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3MOW

Crystal structure of SHP2 in complex with a tautomycetin analog TTN D-1

Summary for 3MOW
Entry DOI10.2210/pdb3mow/pdb
DescriptorTyrosine-protein phosphatase non-receptor type 11, (2Z)-2-[(1R)-3-{[(1R,2S,3R,6S,7S,10S,12S,15E,17E)-18-carboxy-16-ethyl-3,7-dihydroxy-1,2,6,10,12-pentamethyl-5-oxooctade ca-15,17-dien-1-yl]oxy}-1-hydroxy-3-oxopropyl]-3-methylbut-2-enedioic acid (3 entities in total)
Functional Keywordsnatural product, catalytic domain, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: Q06124
Total number of polymer chains1
Total formula weight32932.49
Authors
Zhang, Z.-Y.,Liu, S.,Yu, Z.,Yu, X. (deposition date: 2010-04-23, release date: 2011-05-04, Last modification date: 2023-09-06)
Primary citationZhang, Z.-Y.,Liu, S.,Yu, Z.,Yu, X.,Huang, S.-X.,Luo, Y.,Wu, L.,Yang, Z.,Wang, L.,Gunawan, A.M.,Chan, R.J.,Shen, B.
Crystal structure of SHP2 in complex with a tautomycetin analog TTN D-1
To be Published,
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

217705

數據於2024-03-27公開中

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