3MO7

Crystal structure of human orotidine 5'-monophosphate decarboxylase covalently modified by 2'-fluoro-6-iodo-UMP

3MO7 の概要

• エントリーDOI: 10.2210/pdb3mo7/pdb
• 関連するPDBエントリー: 2EAW 2P1F 3BGG 3BGJ 3BKO 3G3D
• 分子名称: Uridine 5'-monophosphate synthase, 2'-deoxy-2'-fluorouridine 5'-(dihydrogen phosphate), GLYCEROL, ... (4 entities in total)
• 機能のキーワード: ump synthase, orotidine 5'-monophosphate decarboxylase, 2'-fluoro-6-iodo-ump, lyase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30890.43

構造登録者

Liu, Y.,Kotra, L.P.,Pai, E.F. (登録日: 2010-04-22, 公開日: 2011-04-06, 最終更新日: 2023-09-06)

• 主引用文献: Lewis, M.,Meza-Avina, M.E.,Wei, L.,Crandall, I.E.,Bello, A.M.,Poduch, E.,Liu, Y.,Paige, C.J.,Kain, K.C.,Pai, E.F.,Kotra, L.P.; Novel interactions of fluorinated nucleotide derivatives targeting orotidine 5'-monophosphate decarboxylase.; J.Med.Chem., 54:2891-2901, 2011; PubMed: 21417464; DOI: 10.1021/jm101642g

実験手法

X-RAY DIFFRACTION (1.35 Å)