3MNR

Crystal Structure of Benzamide SNX-1321 bound to Hsp90

Summary for 3MNR

• Entry DOI: 10.2210/pdb3mnr/pdb
• Related: 3D0B
• Descriptor: Heat shock protein HSP 90-alpha, 2-[(3,4,5-trimethoxyphenyl)amino]-4-(2,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl)benzamide (3 entities in total)
• Functional Keywords: hsp90, heat shock protein 90, protein-ligand complex, chaperone
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P07900
• Total number of polymer chains: 1
• Total formula weight: 26634.93

Authors

Veal, J.M.,Fadden, P.,Huang, K.H.,Rice, J.,Hall, S.E.,Haytstead, T.A. (deposition date: 2010-04-22, release date: 2010-08-11, Last modification date: 2023-09-06)

• Primary citation: Fadden, P.,Huang, K.H.,Veal, J.M.,Steed, P.M.,Barabasz, A.F.,Foley, B.,Hu, M.,Partridge, J.M.,Rice, J.,Scott, A.,Dubois, L.G.,Freed, T.A.,Silinski, M.A.,Barta, T.E.,Hughes, P.F.,Ommen, A.,Ma, W.,Smith, E.D.,Spangenberg, A.W.,Eaves, J.,Hanson, G.J.,Hinkley, L.,Jenks, M.,Lewis, M.,Otto, J.,Pronk, G.J.,Verleysen, K.,Haystead, T.A.,Hall, S.E.; Application of Chemoproteomics to Drug Discovery: Identification of a Clinical Candidate Targeting Hsp90.; Chem.Biol., 17:686-694, 2010; PubMed: 20659681; DOI: 10.1016/j.chembiol.2010.04.015

Experimental method

X-RAY DIFFRACTION (1.9 Å)