Crystal Structure of Benzamide Tetrahydro-4H-carbazol-4-one bound to Hsp90

Summary for 3D0B

DescriptorHeat shock protein HSP 90-alpha, 2-[(2-methoxyethyl)amino]-4-(4-oxo-1,2,3,4-tetrahydro-9H-carbazol-9-yl)benzamide (3 entities in total)
Functional Keywordshsp90, heat shock protein 90, alternative splicing, atp-binding, chaperone, cytoplasm, nucleotide-binding, phosphoprotein, stress response
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P07900
Total number of polymer chains1
Total molecular weight26534.82
Barta, T.E.,Veal, J.M.,Huang, K.H.,Hall, S.H. (deposition date: 2008-05-01, release date: 2008-06-17, Last modification date: 2011-07-13)
Primary citation
Barta, T.E.,Veal, J.M.,Rice, J.W.,Partridge, J.M.,Fadden, R.P.,Ma, W.,Jenks, M.,Geng, L.,Hanson, G.J.,Huang, K.H.,Barabasz, A.F.,Foley, B.E.,Otto, J.,Hall, S.E.
Discovery of benzamide tetrahydro-4H-carbazol-4-ones as novel small molecule inhibitors of Hsp90
BIOORG.MED.CHEM.LETT., 18:3517-3521, 2008
PubMed: 18511277 (PDB entries with the same primary citation)
DOI: 10.1016/j.bmcl.2008.05.023
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers20 0.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-10-21