3MLX

Crystal structure of anti-HIV-1 V3 Fab 3074 in complex with an MN V3 peptide

Summary for 3MLX

• Entry DOI: 10.2210/pdb3mlx/pdb
• Related: 3MLR 3MLS 3MLT 3MLU 3MLV 3MLW 3MLY 3MLZ
• Descriptor: Human monoclonal anti-HIV-1 gp120 V3 antibody 3074 Fab light chain, Human monoclonal anti-HIV-1 gp120 V3 antibody 3074 Fab heavy chain, HIV-1 gp120 third variable region (V3) crown, ... (4 entities in total)
• Functional Keywords: human monoclonal antibody, fab, hiv-1, gp120, third variable loop, antibody-antigen interaction, immune system
• Biological source: Homo sapiens; More
• Cellular location: Surface protein gp120: Virion membrane ; Peripheral membrane protein . Transmembrane protein gp41: Virion membrane ; Single-pass type I membrane protein : P05877
• Total number of polymer chains: 6
• Total formula weight: 98581.92

Authors

Kong, X.-P. (deposition date: 2010-04-18, release date: 2010-07-14, Last modification date: 2017-11-08)

• Primary citation: Jiang, X.,Burke, V.,Totrov, M.,Williams, C.,Cardozo, T.,Gorny, M.K.,Zolla-Pazner, S.,Kong, X.P.; Conserved structural elements in the V3 crown of HIV-1 gp120.; Nat.Struct.Mol.Biol., 17:955-961, 2010; PubMed: 20622876; DOI: 10.1038/nsmb.1861

Experimental method

X-RAY DIFFRACTION (1.9 Å)