3MLS

Crystal structure of anti-HIV-1 V3 mAb 2557 Fab in complex with a HIV-1 gp120 V3 mimotope

Summary for 3MLS

Related3MLR 3MLT 3MLU 3MLV 3MLW 3MLX 3MLY 3MLZ
DescriptorHuman monoclonal anti-HIV-1 gp120 V3 antibody 2557 Fab light chain, Human monoclonal anti-HIV-1 gp120 V3 antibody 2557 Fab heavy chain, Rationally designed V3 mimotope, ... (4 entities in total)
Functional Keywordshuman monoclonal antibody, fab, hiv-1, gp120, third variable loop, antibody-antigen interaction, mimotope, immune system
Biological sourceHomo sapiens
Total number of polymer chains12
Total molecular weight198429.32
Authors
Kong, X.-P. (deposition date: 2010-04-18, release date: 2010-07-14, Last modification date: 2017-11-08)
Primary citation
Jiang, X.,Burke, V.,Totrov, M.,Williams, C.,Cardozo, T.,Gorny, M.K.,Zolla-Pazner, S.,Kong, X.P.
Conserved structural elements in the V3 crown of HIV-1 gp120.
Nat.Struct.Mol.Biol., 17:955-961, 2010
PubMed: 20622876 (PDB entries with the same primary citation)
DOI: 10.1038/nsmb.1861
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.5 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.274191.1%5.0%5.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution