3MJW

PI3 Kinase gamma with a benzofuranone inhibitor

3MJW の概要

• エントリーDOI: 10.2210/pdb3mjw/pdb
• 分子名称: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, (2Z)-4,6-dihydroxy-2-[(8-methoxy-1,2,3,4-tetrahydropyrazino[1,2-a]indol-10-yl)methylidene]-1-benzofuran-3(2H)-one (2 entities in total)
• 機能のキーワード: atp-binding, kinase, nucleotide-binding, transferase
• 由来する生物種: Homo sapiens
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 111134.54

構造登録者

Bard, J.,Svenson, K. (登録日: 2010-04-13, 公開日: 2010-06-09, 最終更新日: 2023-09-06)

• 主引用文献: Zhang, N.,Ayral-Kaloustian, S.,Anderson, J.T.,Nguyen, T.,Das, S.,Venkatesan, A.M.,Brooijmans, N.,Lucas, J.,Yu, K.,Hollander, I.,Mallon, R.; 5-Ureidobenzofuranone indoles as potent and efficacious inhibitors of PI3 kinase-alpha and mTOR for the treatment of breast cancer.; Bioorg.Med.Chem.Lett., 20:3526-3529, 2010; PubMed: 20483602; DOI: 10.1016/j.bmcl.2010.04.139

実験手法

X-RAY DIFFRACTION (2.87 Å)