3MJ5
Severe Acute Respiratory Syndrome-Coronavirus Papain-Like Protease Inhibitors: Design, Synthesis, Protein-Ligand X-ray Structure and Biological Evaluation
Summary for 3MJ5
Entry DOI | 10.2210/pdb3mj5/pdb |
Related | 2FE8 3E9S |
Descriptor | Replicase polyprotein 1a, N-(1,3-benzodioxol-5-ylmethyl)-1-[(1R)-1-naphthalen-1-ylethyl]piperidine-4-carboxamide, ZINC ION, ... (4 entities in total) |
Functional Keywords | non-covalent inhibitor, cysteine protease, sars coronavirus, zinc-finger, viral protein |
Biological source | SARS coronavirus (SARS-CoV) |
Cellular location | Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity): P0C6U8 |
Total number of polymer chains | 2 |
Total formula weight | 72004.39 |
Authors | Mesecar, A.D.,Ratia, K.M.,Pegan, S.D. (deposition date: 2010-04-12, release date: 2010-06-30, Last modification date: 2024-03-13) |
Primary citation | Ghosh, A.K.,Takayama, J.,Rao, K.V.,Ratia, K.,Chaudhuri, R.,Mulhearn, D.C.,Lee, H.,Nichols, D.B.,Baliji, S.,Baker, S.C.,Johnson, M.E.,Mesecar, A.D. Severe acute respiratory syndrome coronavirus papain-like novel protease inhibitors: design, synthesis, protein-ligand X-ray structure and biological evaluation J.Med.Chem., 53:4968-4979, 2010 Cited by PubMed: 20527968DOI: 10.1021/jm1004489 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.63 Å) |
Structure validation
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