3MJ5
Severe Acute Respiratory Syndrome-Coronavirus Papain-Like Protease Inhibitors: Design, Synthesis, Protein-Ligand X-ray Structure and Biological Evaluation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Replicase polyprotein 1a | polymer | 316 | 35520.3 | 2 | UniProt (P0C6U8) Pfam (PF08715) In PDB | SARS coronavirus (SARS-CoV) | pp1a, ORF1a polyprotein, Non-structural protein 1, nsp1, Leader protein, Non-structural protein 2, nsp2, p65 homolog, Non-structural protein 3, nsp3, Papain-like proteinase, PL-PRO, PL2-PRO, Non-structural protein 4, nsp4, 3C-like proteinase, 3CL-PRO, 3CLp, nsp5, Non-structural protein 6, nsp6, Non-structural protein 7, nsp7, Non-structural protein 8, nsp8, Non-structural protein 9, nsp9, Non-structural protein 10, nsp10, Growth factor-like peptide, GFL, Non-structural protein 11, nsp11 |
| 2 | A, B | N-(1,3-benzodioxol-5-ylmethyl)-1-[(1R)-1-naphthalen-1-ylethyl]piperidine-4-carboxamide | non-polymer | 416.5 | 2 | Chemie (GRM) | |||
| 3 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | water | water | 18.0 | 119 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 316 (UniProt: P0C6U8)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 71040.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 963.8 | |
| All* | Total formula weight | 72004.4 |
