3MIY
X-ray crystal structure of ITK complexed with sunitinib
Summary for 3MIY
Entry DOI | 10.2210/pdb3miy/pdb |
Related | 3MJ1 3MJ2 |
Descriptor | Tyrosine-protein kinase ITK/TSK, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide (3 entities in total) |
Functional Keywords | helix c-in, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q08881 |
Total number of polymer chains | 2 |
Total formula weight | 61029.78 |
Authors | Kuglstatter, A.,Villasenor, A.G. (deposition date: 2010-04-12, release date: 2010-06-30, Last modification date: 2023-09-06) |
Primary citation | Kutach, A.K.,Villasenor, A.G.,Lam, D.,Belunis, C.,Janson, C.,Lok, S.,Hong, L.N.,Liu, C.M.,Deval, J.,Novak, T.J.,Barnett, J.W.,Chu, W.,Shaw, D.,Kuglstatter, A. Crystal structures of IL-2-inducible T cell kinase complexed with inhibitors: insights into rational drug design and activity regulation. Chem.Biol.Drug Des., 76:154-163, 2010 Cited by PubMed: 20545945DOI: 10.1111/j.1747-0285.2010.00993.x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.67 Å) |
Structure validation
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